Tamika Mkandwire and Simon Church will be missing for the O’s, but Adam Boyd and Adam Chambers will be back in contention after injury.
Tammy will be out for at least two weeks after picking up a starin to his knee, but Simon Church was on duty with the Welsh Under 21 team.
(They drew 0-0 on Friday night with Luxemborg)
New Oldham manager Joe Royle has allowed Lee Hughes to go on loan to Blackpool but still has Steven Kabba, Deanne Smalley and Lewis Allesandra to choose from for the forward slots.
Oldham are also without Neil Eardley to the Welsh Under 21 team.
The betting odds see Orient generally available at 6/4
with a draw 2/1 and Oldham 5/4 to 11/8.